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"In-phantom dosimetry using the 13C(d,n)14n reaction for BNCT"
A. Burlón, A.J. Kreiner, S. White, J.C. Yanch, B. Blackburn and D. Gierga
Proc. of the "9th International Symposium on Neutron Capture Therapy for Cancer", International Convention Center, Osaka, Japan, October 2-6, 2000.
Program and Abstracts of the Ninth International Symposium on Neutron Capture Therapy for Cancer (NCT OSAKA 2000), KUR Reports, Osaka (2000) 53
The use of the 13C(d,n)14N reaction at Ed =1.5 MeV for accelerator-based boron neutron capture therapy is investigated. Among the deuteron-induced reactions at low incident energy, the 13C(d,n)14N reaction is one of the best because of the advantages of carbon as a target material and its large cross section. The deuteron beam was produced by a tandem accelerator at MIT's Laboratory for Accelerator Beam Applications. The resulting neutron spectra were evaluated in terms of RBE-dose rates at different depths inside a water-filled brain phantom using a heavy water moderator and lead reflector assembly. Dosimetry results were obtained using the dual ionization chamber technique for fast neutrons and photons and bare and cadmium-covered gold foils for the thermal neutron flux. The RBE-doses in tumor and healthy tissue were calculated from experimental data assuming a tumor 10B concentration of 40 ppm and a healthy tissue 10B concentration of 11 ppm. All results were simulated using the code MCNP, a Monte Carlo neutron and photon transport code. A treatment time of 90 minutes was obtained for a tumor located at 5.7 cm depth within the brain, assuming a 20 RBE-Gy dose in a single beam session and a 4 mA deuteron current.
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