Página Inicial CNEA Laboratorio TANDAR Página Inicial TANDAR Historia del acelerador TANDAR Web interno Web mail
Inicio » Actividades I+D > Publicaciones 2001 > 1-(2-{4-[6-Hydroxy-2-(4-hydroxyphenyl)be...
artículo con referato
"1-(2-{4-[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiol-3-ylcarbonyl]phenoxy}ethyl)piperidinium chloride"
D. Vega, D. Fernández and J.A. Ellena
Acta Cryst. C 57(9) (2001) 1092-1094
The title compound, raloxifene hydrochloride, C28H28NO4S+·Cl-, belongs to the benzothiophene class of antiosteoporotic drugs. In the molecular cation, the 2-phenol ring sustains a dihedral angle of 45.3 (1)° relative to the benzo[b]thiophene system. The benzo[b]thiophene and phenyl ring planes are twisted with respect to the carbonyl plane, with the smallest twist component occurring between the phenyl and carbonyl planes. The N atom bears the positive charge in the molecular cation and the piperidine ring adopts an almost perfect chair conformation. The Cl- anion is involved in the formation of N–HCl and O–HCl intermolecular hydrogen bonds, which lead to the formation of a layer of molecular cations.
Av. Gral Paz y Constituyentes, San Martín, Pcia. de Buenos Aires, Argentina
Tel: (54-11) 6772-7007 - Fax: (54-11) 6772-7121