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Inicio » Actividades I+D > Publicaciones 2002 > Losartan potassium, a non-peptidic agent...
artículo con referato
"Losartan potassium, a non-peptidic agent for the treatment of arterial hypertension"
D. Fernández, D. Vega, J.A. Ellena and G. Echeverría
Acta Cryst. C 58(7) (2002) m418-m420
In the title compound, potassium 2-butyl-4-chloro-1-{[2′-(5-tetrazolido)biphenyl-4-yl]methyl}-1H-imidazol-5-ylmethanol, K+·C22H22ClN6O-, the imidazole and tetrazole rings are at angles of 85.0 (2) and 51.8 (1)°, respectively, to the phenyl rings to which they are attached, while the dihedral angle between the latter two rings is 46.7 (1)°. The coordination sphere of the metal cation consists of six tetrazoyl N atoms, the methanol O atom and the π cloud of one of the phenyl rings. These interactions determine the formation of columns of molecular anions that lie parallel to the b axis, while hydrogen bonding contributes to intercolumnar cohesion. Far from the centre of the columns, the hydrocarbon chain is immersed in a hydrophobic environment.
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