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artículo con referato
"The calcium-binding properties of pamidronate, a bone-resorption inhibitor"
D. Fernández, D. Vega and A. Goeta
Acta Cryst. C 58(19) (2002) m494-m497
The title compound, calcium bis(3-ammonio-1-hydroxypropylidene-1,1-bisphosphonate) dihydrate, Ca2+·2C3H10NO7P2-·2H2O, consists of calcium octahedra arranged in columns along the c axis and coordinated by hydrogen-bonded molecular anions. The Ca2+ cation lies on a twofold axis. Pamidronate adopts a twisted conformation of the hydroxyalkylamine backbone that enables the formation of an intramolecular N–HO hydrogen bond. The molecular anion is chelating monodentate as well as bidentate, with an OO bite distance of 3.0647 (15) Å.
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