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"RBE Measurements of Low Energy Proton, Alpha and Lithium Beams on Melanoma Cell Lines"
J.A. Schuff, L. Policastro, H. Durán, A.J. Kreiner, A. Mazal, B.L. Molinari, A.A. Burlón, J. Davidson, M. Davidson, M.E. Debray, M. Edreira, J.M. Kesque, M.J. Ozafrán, E. Rivera, H. Somacal, P. Stoliar, A.A. Valda and M.E. Vázquez
Proc. of the "10th International Congress on Neutron Capture Therapy" (10-ICNCT), Essen, Germany, September 8-13, 2002. Ed. W.A.G. Sauerwein, R.L. Moss and A. Wittig
Research and Development in Neutron Capture Therapy, International Proceedings Division, Monduzzi Editore, Bologna (2002) 701-707
ISBN: 978-883232909-4
The knowledge of Relative Biological Effectiveness values (RBEs) for low-energy protons, alpha particles and Li ions is of the utmost importance in connection with BNCT. Treatment planning and equivalent-dose assessment cannot be reliably carried through without the knowledge of RBE's. The cell inactivation effects of low energy protons, alpha particles and Li ions originating from the 14N(n, p)14C and 10B(n,α)7Li capture reactions and elastic collisions of fast neutrons can be experimentally simulated to a certain extent by low-energy beams produced by an accelerator and this knowledge may be a contribution to the success of BNCT. In this kind of measurement, where a cell culture is irradiated by a uniform beam, an RBE value can be obtained which could in turn be convoluted with the boron microdistribution function to get the Compound Biological Effectiveness (CBE) factor. External proton, alpha and 6,7Li beams were produced at the TANDAR accelerator in Buenos Aires with the aim of initiating radiobiology studies on cell cultures and also on small animals. In this paper we briefly present the instrumentation and dosimetric characterization of a dedicated beam for radiobiological studies, and the measured RBE10 (at 10% survival), as a function of energy, for protons (1-14 MeV), alphas (2-18 MeV) and 6,7Li (4-14 MeV), with Linear Energy Transfers, LETs, ranging from 3.4 (for protons of 14.2 MeV) to 310 keV/mm (7Li at 3.8 MeV), for different melanoma cell lines: human melanoma WM35 and murine B16-F0. The LET range studied for alpha and Li ions covers the one relevant for the 7Li fragment in the BNCT capture reaction. The RBE10 values determined here for the first time for these cell lines, first increase as a function of LET to finally decrease for the highest value of LET for both melanoma cell lines, reproducing a known behavior. As an example, RBE values for WM35 and Li are: 3.9± 0.2 for 13.7 MeV and 2.0± 0.2 for 3.8 MeV midplane energy.
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