Página Inicial CNEA Laboratorio TANDAR Página Inicial TANDAR Historia del acelerador TANDAR Web interno Web mail
Inicio » Actividades I+D > Publicaciones 2003 > 17α,21-Dihydroxy-16β-methylpregna-1,4-di...
artículo con referato
"17α,21-Dihydroxy-16β-methylpregna-1,4-diene-3,11,20-trione (meprednisone)"
D. Fernández, D.R. Vega and J.A. Ellena
Acta Cryst. C 59(4) (2003) o187-o189
The title compound, C22H28O5, is a commercial therapeutic agent of the steroid class. Both independent molecules in the asymmetric unit have six-membered A rings that are planar, while the B and C rings adopt normal chair conformations. The five-membered D ring is in a 13β,14α-half-chair conformation, and the B/C and C/D ring junctions are in trans positions. Cohesion in the crystal is provided by O–HO hydrogen bonds, which generate chains of molecules that are organized in a plane that lies along the crystallographic b axis.
Av. Gral Paz y Constituyentes, San Martín, Pcia. de Buenos Aires, Argentina
Tel: (54-11) 6772-7007 - Fax: (54-11) 6772-7121