The title compound, C₂₂H₂₈O₅, is a commercial therapeutic agent of the steroid class. Both independent molecules in the asymmetric unit have six-membered A rings that are planar, while the B and C rings adopt normal chair conformations. The five-membered D ring is in a 13β,14α-half-chair conformation, and the B/C and C/D ring junctions are in trans positions. Cohesion in the crystal is provided by O–H⋯O hydrogen bonds, which generate chains of molecules that are organized in a plane that lies along the crystallographic b axis.