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Inicio » Actividades I+D > Publicaciones 2003 > Head-to-head dimers in the zwitterion of...
artículo con referato
"Head-to-head dimers in the zwitterion of 1-hydroxy-3-(pyrrolidin-1-yl)propylidene-1,1-bisphosphonic acid (EB 1053)"
D. Fernández and D. Vega
Acta Cryst. C 59(5) (2003) o228-o230
The title compound, 1-hydroxy-1-phosphono-3-(1-pyrrolidinio)propylidene-1-phosphonate, C7H17NO7P2, is a member of the bisphosphonate class of drugs. As a zwitterion, it possesses a negative charge on one of the PO3 groups and a positive charge on the pyrrolidine N atom. A zwitterion makes a contact with a neighbouring ion through the hydroxyl O atom and two phosphonyl O atoms, one each from two different PO3 groups. Hydrogen bonding involves O–HO and N–HO interactions; the former are involved in the formation of head-to-head dimers, while the latter join the dimers into a chain running along the crystallographic b axis.
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