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artículo con referato
"A Two-step Method for the Preparation of Chiral Cathinones"
M. Osorio-Olivares, M.C. Rezende, S. Sepúlveda-Boza, B.K. Cassels, R.F. Baggio and J.C. Muñoz Acevedo
Tetrahedron: Asymmetry 14(11) (2003) 1473-1477
A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2(“cathinones”) is described, involving initial Friedel-Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the structures.
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