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Inicio » Actividades I+D > Publicaciones 2005 > Candesartan cilexetil, an antihypertensi...
artículo con referato
"Candesartan cilexetil, an antihypertensive agent containing an extended double ester chain"
D. Fernández, D. Vega and J.A. Ellena
Acta Cryst. E 61(2) (2005) o309-o312
In the title compound (systematic name: (±)-1-[(cyclohexyloxy)carbonyloxy]ethyl 2-ethoxy-1-{[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate), C33H34N6O6, the biphenyltetrazole moiety projects almost perpendicularly from the benzimidazole group. The planes of the three rings in the biphenyltetrazole moiety are staggered with respect to one another. In the benzimidazole system, the 2-ethoxy group is extended in the opposite direction with respect to the CH(Me)OCOO-c-hexyl double ester chain. An N–HN hydrogen bond joins [010]-translated molecules to form a chain running along the b axis.
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