Página Inicial CNEA Laboratorio TANDAR Página Inicial TANDAR Historia del acelerador TANDAR Web interno Web mail
Inicio » Actividades I+D > Publicaciones 2010 > Thermal stability of aripiprazole monohy...
artículo con referato
"Thermal stability of aripiprazole monohydrate investigated by Raman spectroscopy"
A.P. Ayala, S.B. Honorato, J. Mendes Filho, D. Grillo, M. Quintero, F. Gilles and G. Polla
Vib. Spectrosc. 54(2) (2010) 169-173
Aripiprazole (7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril) is a well-known antipsychotic oral drug, whose molecular structure makes it suitable for polymorphism. Several crystalline structures were reported in the literature including anhydrate, hydrate and solvate modifications. It was observed that aripiprazole monohydrate exhibit a complex dehydration dynamics which was not completely elucidated. In this work the dehydration process of the aripiprazole hydrate was investigated by using Raman scattering, hot-stage microscopy and differential scanning calorimetry. The temperature evolution of the Raman spectra was analyzed through the multivariate statistical method of principal component analysis. Our results support that the dehydration process of aripiprazole is divided in two steps. First a diffusion-controlled loss of water followed by a fast nucleation and crystallization of the anhydrous form.
Av. Gral Paz y Constituyentes, San Martín, Pcia. de Buenos Aires, Argentina
Tel: (54-11) 6772-7007 - Fax: (54-11) 6772-7121