The title compound, [Co(C₅H₇N₆)₂(H₂O)₄](C₁₀H₂O₈)·4H₂O, is an ionic structure comprising a [Co(Hdap)₂(H₂O)₄]⁴⁺ cation (dap is 2,6-diaminopurine) in a general position, two benzene-1,2,4,5-tetracarboxylate (btc^4-) anions straddling two different inversion centres and four solvent water molecules. The structure presents a remarkable degree of pseudosymmetry, with the Co^II cation lying almost exactly on a noncrystallographic pseudo-inversion centre. The overall spatial arrangement can be described in terms of cationic and anionic chains running along the [111] direction and linked into a three-dimensional network by a very complex hydrogen-bonding scheme in which all the available N-H and O-H groups take part.