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Inicio » Actividades I+D > Publicaciones 2012 > Aripiprazole salts. I. Aripiprazole nitr...
artículo con referato
"Aripiprazole salts. I. Aripiprazole nitrate"
E. Freire, G. Polla and R. Baggio
Acta Cryst. C 68(4) (2012) o170-o173
The crystal structure of aripiprazole nitrate (systematic name: 4-(2,3-dichlorophenyl)-1-{4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl}piperazin-1-ium nitrate), C23H28Cl2N3O2+·NO3- or AripH+·NO3-, is presented and the molecule compared with the aripiprazole molecules reported so far in the literature. Bond distances and angles appear very similar, except for a slight lengthening of the C-NH distances involving the protonated N atom, and the main differences are to be found in the molecular spatial arrangement (revealed by the sequence of torsion angles) and the intermolecular interactions (resulting from structural elements specific to this structure, viz. the nitrate counter-ions on one hand and the extra protons on the other hand as hydrogen-bond acceptors and donors, respectively). The result is the formation of [100] strips, laterally linked by weak ππ and C–Clπ interactions, leading to a family of undulating sheets parallel to (010).
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