Página Inicial CNEA Laboratorio TANDAR Página Inicial TANDAR Historia del acelerador TANDAR Web interno Web mail
Inicio » Actividades I+D > Publicaciones 2015 > Discussing Endogenous NO•/HNO Interconve...
artículo con referato
"Discussing Endogenous NO/HNO Interconversion Aided by Phenolic Drugs and Vitamins"
Mariana Hamer, Sebastian A. Suarez, Nicolás I. Neuman, Lucía Alvarez, Martina Muñoz, Marcelo A. Marti and Fabio Doctorovich
Inorg. Chem. 54(19) (2015) 9342-9350
The reduction of NO to HNO/NO under biologically compatible conditions has always been thought as unlikely, mostly because of the negative reduction potential: E°(NO,H+/HNO) = -0.55 V vs NHE at physiological pH. Nonetheless, during the past decade, several works hinted at the possible NO-to-HNO conversion mediated by moderate biological reductants. Very recently, we have shown that the reaction of NO with ascorbate and aromatic alcohols occurs through a proton-coupled nucleophilic attack (PCNA) of the alcohol to NO, yielding an intermediate RO-N(H)O species, which further decomposes to release HNO. For the present work, we decided to inspect whether other common biological aromatic alcohols obtained from foods, such as Vitamin E, or used as over-the-counter drugs, like aspirin, are able to undergo the reaction. The positive results suggest that the conversion of NO to HNO could occur far more commonly than previously expected. Taking these as the starting point, we set to review our and other groups. previous reports on the possible NO-to-HNO conversion mediated by biological compounds including phenolic drugs and vitamins, as well as several thiol-bearing compounds. Analysis of revised data prompted us to ask ourselves the following key questions: What are the most likely physio/pathological conditions for NO-to-HNO conversion to take place? Which effects usually attributed to NO are indeed mediated by HNO? These inquiries are discussed in the context of 2 decades of NO and HNO research.
Av. Gral Paz y Constituyentes, San Martín, Pcia. de Buenos Aires, Argentina
Tel: (54-11) 6772-7007 - Fax: (54-11) 6772-7121