Página Inicial CNEA Laboratorio TANDAR Página Inicial TANDAR Historia del acelerador TANDAR Web interno Web mail
Inicio » Actividades I+D > Publicaciones 2015 > Studies of endothelial monolayer formati...
acta de conferencia
"Studies of endothelial monolayer formation on irradiated poly-L-lactide acid with ions of different stopping power and velocity"
Claudia R. Arbeitman, Mariela F. del Grosso, Irene L. Ibañez, Moni Behar, Mariano Grasselli and Gerardo García Bermúdez
Proc. of the "9th International Symposium on Swift Heavy Ions in Matter", Darmstadt, Germany, May 18-21, 2015. Ed. Christina Trautmann, Hermann Rothard and Daniel Severin
Nucl. Instrum. Meth. B 365, Part B (2015) 587-591
In this work we study cell viability, proliferation and morphology of bovine aortic endothelial cells (BAEC) cultured on poly-L-lactide acid (PLLA) modified by heavy ion irradiation. In a previous study comparing ions beams with the same stopping power we observed an increase in cell density and a better cell morphology at higher ion velocities. In the present work we continued this study using heavy ions beam with different stopping power and ion velocities. To this end thin films of 50 µm thickness were irradiated with 2 MeV/u and 0.10 MeV/u ion beams provided the Tandar (Buenos Aires, Argentina) and Tandetron (Porto Alegre, Brazil) accelerators, respectively. The results suggest that a more dense and elongated cell shapes, similar to the BAEC cells on the internal surface of bovine aorta, was obtained for stopping power of 18.2–22.1 MeV cm2 mg-1 and ion velocity of 2 MeV/u. On the other hand, for low ion velocity 0.10 MeV/u the cells present a more globular shapes.
Av. Gral Paz y Constituyentes, San Martín, Pcia. de Buenos Aires, Argentina
Tel: (54-11) 6772-7007 - Fax: (54-11) 6772-7121