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Inicio » Actividades I+D > Publicaciones 2016 > gem-Diol and Hemiacetal Forms in Formylp...
artículo con referato
"gem-Diol and Hemiacetal Forms in Formylpyridine and Vitamin-B6-Related Compounds: Solid-State NMR and Single-Crystal X-ray Diffraction Studies"
Ayelén Florencia Crespi, Daniel Vega, Ana Karina Chattah, Gustavo Alberto Monti, Graciela Yolanda Buldain and Juan Manuel Lázaro-Martínez
J. Phys. Chem. A 120(39) (2016) 7778-7785
The gem-diol moieties of organic compounds are rarely isolated or even studied in the solid state. Here, liquid- and solid-state NMR, together with single-crystal X-ray diffraction studies, were used to show different strategies to favor the gem-diol or carbonyl moieties and to isolate hemiacetal structures in formylpyridine and vitamin-B6-related compounds. The change in position of the carbonyl group in pyridine compounds had a clear and direct effect on the hydration, which was enhanced by trifluoroacetic acid addition. Because of their biochemical importance, vitamin-B6-related compounds were studied with emphasis on the elucidation of the gem-diol, cyclic hemiacetal or carbonyl structures that can be obtained in different experimental conditions. In particular, new racemic mixtures for the cyclic hemiacetal structure from pyridoxal are reported in trifluoroacetate and hydrochloride derivatives.
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